ALPI

Also known as IAP, alkaline phosphatase, intestinal

Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene. Its chemical formula is:C2679H4196O965N672S18P2.

Gene data

ALPI

Name: alkaline phosphatase, intestinal
Type: protein-coding
Aliases: IAP

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014].

via MyGene.info

Gene · Ensembl

alkaline phosphatase, intestinal

Symbol: ALPI
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:232,456,125-232,460,753
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 134333
exact match: identifiers.org/ncbigene/248
genomic end: 232460753
genomic start: 232456125
cytogenetic location: 2q37.1

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Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene. Its chemical formula is:C2679H4196O965N672S18P2.

Intestinal alkaline phosphatase is an endogenous enzyme that maintains gut homeostasis. It detoxifyies bacterial toxins, dephosphorylates phosphorylated nucleotides, regulates lipid absorption in the intestine, and regulates the microbiome in the intestine. In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.