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GeneQ18030406· pop 5· linked from 446 articles

PDE4A

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Also known as DPDE2, PDE4, PDE46, phosphodiesterase 4A

'''cAMP-specific 3',5'-cyclic phosphodiesterase 4A' is an enzyme that in humans is encoded by the PDE4A'' gene.

Gene data

PDE4A
Name
phosphodiesterase 4A
Type
protein-coding
Position
10,416,773–10,469,816 (+)
Aliases
DPDE2, PDE4, PDE46
Ensembl
ENSG00000065989
RefSeq RNA
NM_001111307.2, NM_001111308.1, NM_001111309.1, NM_001243121.2, NM_006202.3
RefSeq protein
NP_001104777.1, NP_001104778.1, NP_001104779.1, NP_001230050.1, NP_006193.1

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Gene Ontology

Pathways

Purine metabolism - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Opioid SignallingSignal TransductionDARPP-32 eventsSignaling by GPCRGPCR downstream signallingG alpha (s) signalling events

via MyGene.info

Gene · Ensembl

phosphodiesterase 4A

Symbol
PDE4A
Biotype
Protein coding
Organism
Homo sapiens
Location
19:10,416,773-10,469,816
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein PDE4A PDB 1loi.png
Show 8 more facts
HomoloGene ID
4520
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/5141
genomic end
10469630
genomic start
10527449
chromosome
human chromosome 19
cytogenetic location
19p13.2
expressed in
anterior cingulate cortex
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Function
  • Clinical significance
  • References
  • Further reading

'''cAMP-specific 3',5'-cyclic phosphodiesterase 4A' is an enzyme that in humans is encoded by the PDE4A'' gene.

== Function ==

Excerpted from Wikipedia’s “PDE4A” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0