BAIAP2

Also known as BAP2, FLAF3, IRSP53, BAI1 associated protein 2, BAR/IMD domain containing adaptor protein 2, WAML

Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene.

In the Vinony graph

Within Vinony's link graph, BAIAP2 is referenced by 10 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 17.

Its subject is documented across 5 Wikipedia language editions.

Gene data

BAIAP2

Name: BAR/IMD domain containing adaptor protein 2
Type: protein-coding
Position: 81,035,122–81,117,434 (+)
Aliases: BAP2, DEE120, FLAF3, IRSP53, WAML
Ensembl: ENSG00000175866
RefSeq RNA: NM_001144888.2, NM_001385127.1, NM_001385128.1, NM_001385129.1, NM_001385130.1
RefSeq protein: NP_001138360.1, NP_001372056.1, NP_001372057.1, NP_001372058.1, NP_001372059.1

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].