becaplermin
Sign in to saveAlso known as PDGF B-chain, platelet-derived growth factor BB, PDG109, Platelet-derived growth factor B chain precursor, PDGF-2, c-sis, Regranex, Platelet-derived growth factor beta polypeptide
Becaplermin, sold under the brand name Regranex, is a cicatrizant, available as a topical gel. Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers. It is also known as "platelet-derived growth factor BB".
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 458285090
- Drug.tradename
- Regranex
- Drug.MedlinePlus
- a699049
- Drug.routes_of_administration
- Topical
- Drug.ATC_prefix
- A01
- Drug.ATC_suffix
- AD08
- Drug.ATC_supplemental
- ,
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 165101-51-9
- Drug.DrugBank
- DB00102
- Drug.UNII
- 1B56C968OA
- Drug.ChEMBL
- 1201556
- Drug.ChemSpiderID
- none
via Wikipedia infobox
Research
5,114 papers- Becaplermin gel in the treatment of diabetic neuropathic foot ulcers.Clinical interventions in aging · 2008
- Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers.Expert opinion on biological therapy · 2002
- Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers.Drug safety · 2010
- Protein detection using proximity-dependent DNA ligation assays.Nature biotechnology · 2002
- Bone-derived PDGF-BB drives brain vascular calcification in male mice.The Journal of clinical investigation · 2023
via PubMed
Wikidata facts
Show 1 more fact
- World Health Organisation international non-proprietary name
- becaplermin
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- References
Becaplermin, sold under the brand name Regranex, is a cicatrizant, available as a topical gel. Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers. It is also known as "platelet-derived growth factor BB".
==Medical uses== Becaplermin is used for the treatment of diabetic foot ulcers. Studies of becaplermin showed that when used with good wound care, complete healing significantly increased and the ulcers healed on average 6 weeks faster. Pharmacoeconomic studies reinforce the cost effectiveness of becaplermin as an adjunct to good wound care.