benoxaprofen
Sign in to saveAlso known as Oraflex, Compound 90459, 2-[2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid, (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid, DL-benoxaprofen, 2-(2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl)propanoic acid, 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid, Benoxaprofene
Benoxaprofen, also known as benoxaphen, is a chemical compound with the formula C16H12ClNO3. It is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid class, and was marketed under the brand name Opren in the United Kingdom and Europe by Eli Lilly and Company (commonly referred to as Lilly), and as Oraflex in the United States of America (USA). Lilly suspended sales of Oraflex in 1982 after reports from the British government and the United States Food and Drug Administration (US FDA) of adverse effects and deaths linked to the drug.
Research
429 papers- Benoxaprofen.The Medical journal of Australia · 1983
- Benoxaprofen.British medical journal (Clinical research ed.) · 1982
- Benoxaprofen.British medical journal (Clinical research ed.) · 1982
- Benoxaprofen.British medical journal (Clinical research ed.) · 1982
- Benoxaprofen and the skin.The British journal of dermatology · 1983
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 301.050571
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₆H₁₂ClNO₃
- canonical SMILES
- CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)Cl)C(=O)O
- World Health Organisation international non-proprietary name
- benoxaprofen
- Commons category
- Benoxaprofen
Sources (2)
via Wikidata · CC0
~14 min read
Encyclopedic overview
16 sectionsContents
- History
- Structure and reactivity
- Available forms
- Toxicokinetics
- Toxicodynamics
- Efficacy and side effects
- Efficacy
- Adverse effects
- Cutaneous side effects
- Gastrointestinal side effects
- Side effects in the central nervous system
- Miscellaneous side effects
- Toxicity
- Effects on animals
- Synthesis
- References
Benoxaprofen, also known as benoxaphen, is a chemical compound with the formula C16H12ClNO3. It is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid class, and was marketed under the brand name Opren in the United Kingdom and Europe by Eli Lilly and Company (commonly referred to as Lilly), and as Oraflex in the United States of America (USA). Lilly suspended sales of Oraflex in 1982 after reports from the British government and the United States Food and Drug Administration (US FDA) of adverse effects and deaths linked to the drug.
==History== Benoxaprofen was discovered by a team of research chemists at the British Lilly Research Centre of Eli Lilly and Company . This laboratory was assigned to explore new anti-arthritic compounds in 1966. Lilly applied for patents on its then named new drug 'benoxaprofen' seven years later. It also filed for permission from the U.S. Food and Drug Administration to start testing benoxaprofen on humans. It had to undergo the three-step clinical testing procedure required by the United States Federal Government.
Excerpted from Wikipedia’s “benoxaprofen” article, available under the CC BY-SA 4.0 licence.