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GeneQ14905625· pop 11· linked from 514 articles

CALCR

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Also known as CRT, CT-R, CTR, CTR1, calcitonin receptor

protein-coding gene in the species Homo sapiens

Gene data

CALCR

Name: calcitonin receptor
Type: protein-coding
Position: 93,424,486–93,575,738 (−)
Aliases: CRT, CT-R, CTR, CTR1
Ensembl: ENSG00000004948
RefSeq RNA: NM_001164737.3, NM_001164738.2, NM_001742.4
RefSeq protein: NP_001158209.2, NP_001158210.1, NP_001733.1

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

Gene Ontology

Biological process

cell surface receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration

Molecular function

amyloid-beta binding calcitonin gene-related peptide receptor activity calcitonin gene-related peptide receptor activity transmembrane signaling receptor activity G protein-coupled receptor activity calcitonin receptor activity calcitonin receptor activity calcitonin receptor activity

Cellular component

acrosomal vesicle plasma membrane plasma membrane plasma membrane plasma membrane cilium membrane axon

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)Signal Transduction Signaling by GPCR Class B/2 (Secretin family receptors)GPCR downstream signalling G alpha (s) signalling events Calcitonin-like ligand receptors GPCR ligand binding RANKL-RANK signaling pathway

via MyGene.info

Gene · Ensembl

calcitonin receptor

Symbol: CALCR
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:93,424,486-93,575,738
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

HomoloGene ID: 1320
exact match: identifiers.org/ncbigene/799
genomic end: 93204042
genomic start: 93424486
cytogenetic location: 7q21.3
Commons category: Calcitonin receptor

Sources (5)

via Wikidata · CC0

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 7 G protein-coupled receptors