CD8
Also known as CD8-receptor, CD8 antigens, CD8 molecule, CD8 receptor, CD8 protein
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.
Key facts
- Protein family.Symbol
- CD8
- Protein family.Name
- Putative T-cell surface glycoprotein CD8
- Protein family.caption
- Crystallographic structure of the extracellular domain of CD8 molecule.
- Protein family.Membranome family
- 29
- Protein.Name
- CD8b molecule
- Protein.HGNCid
- 1707
- Protein.Symbol
- CD8B
- Protein.AltSymbols
- CD8B1
- Protein.EntrezGene
- 925
- Protein.OMIM
- 186910
- Protein.RefSeq
- NM_001768
- Protein.UniProt
- P01732
Article · 日本語
CD8はT細胞受容体の共受容体として働く膜貫通糖タンパク質である。T細胞受容体と同様に主要組織適合抗原(MHC)に結合するが、MHC-Iと特異的に結合する 。CD8にはαとβの2種類のアイソフォームが知られ、それぞれ異なる遺伝子から翻訳される。ヒトの場合、両遺伝子とも2番染色体の2p12遺伝子座に位置する。
Abstract from DBpedia / Wikipedia · CC BY-SA