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complement C3d receptor 2
Sign in to saveAlso known as complement component (3d/Epstein Barr virus) receptor 2, Epstein-Barr virus receptor, complement receptor type 2, CR2, Complement C3d receptor, complement component 3d receptor 2, EBV receptor, CD21
mammalian protein found in Homo sapiens
Protein · UniProt
Complement receptor type 2
- Gene
- CR2
- Organism
- Homo sapiens (Human)
- Length
- 1,033 aa
- Molecular mass
- 112,916 Da
- Evidence
- 1: Evidence at protein level
Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed:1849076, PubMed:21527715, PubMed:7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed:21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed:1383329, PubMe…
Swiss-Prot (reviewed) · via UniProt
Research
390 papers- C3-dependent effector functions of complement.Immunological reviews · 2023
- Structure of complement receptor (CR) 2 and CR2-C3d complexes.Biochemical Society transactions · 2002
- Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine.AIDS (London, England) · 2020
- The Structure-Function Relationships of Complement Receptor Type 2 (CR2; CD21).Current protein & peptide science · 2016
- Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.Journal of molecular biology · 2010
via PubMed