CLDN18
Sign in to saveAlso known as SFTA5, SFTPJ, claudin 18
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
In the Vinony graph
Within Vinony's link graph, CLDN18 is referenced by 4 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 7 Wikipedia language editions.
Gene data
CLDN18- Name
- claudin 18
- Type
- protein-coding
- Position
- 137,998,735–138,033,655 (+)
- Aliases
- SFTA5, SFTPJ
- Ensembl
- ENSG00000066405
- RefSeq RNA
- NM_001002026.3, NM_016369.4
- RefSeq protein
- NP_001002026.1, NP_057453.1
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
claudin 18
- Symbol
- CLDN18
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:137,998,735-138,033,655
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 9489
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51208
- genomic end
- 137752494
- genomic start
- 137717577
- chromosome
- human chromosome 3
- cytogenetic location
- 3q22.3
- expressed in
- fundus
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- References
- External links
- Further reading
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]
Excerpted from Wikipedia’s “CLDN18” article, available under the CC BY-SA 4.0 licence.