CLCNKB
Sign in to saveAlso known as CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb
Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.
In the Vinony graph
Within Vinony's link graph, CLCNKB is referenced by 360 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 1 and Ion channels.
Its subject is documented across 7 Wikipedia language editions.
Gene data
CLCNKB- Name
- chloride voltage-gated channel Kb
- Type
- protein-coding
- Position
- 16,040,252–16,057,367 (+)
- Aliases
- CLCKB, ClC-K2, ClC-Kb
- Ensembl
- ENSG00000184908
- RefSeq RNA
- NM_000085.5, NM_001165945.2
- RefSeq protein
- NP_000076.2, NP_001159417.2
The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
chloride voltage-gated channel Kb
- Symbol
- CLCNKB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:16,040,252-16,057,367
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 65
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1188
- genomic end
- 16057311
- genomic start
- 16040252
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.13
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.
Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome. CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.
Excerpted from Wikipedia’s “CLCNKB” article, available under the CC BY-SA 4.0 licence.