CLCNKB

Also known as CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.

Gene data

CLCNKB

Name: chloride voltage-gated channel Kb
Type: protein-coding
Aliases: CLCKB, ClC-K2, ClC-Kb

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

via MyGene.info

Gene · Ensembl

chloride voltage-gated channel Kb

Symbol: CLCNKB
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:16,040,252-16,057,367
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 65
exact match: identifiers.org/ncbigene/1188
genomic end: 16057311
genomic start: 16040252
cytogenetic location: 1p36.13

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Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome. CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.