DUSP19

Also known as DUSP17, LMWDSP3, SKRP1, TS-DSP1, dual specificity phosphatase 19

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.

Gene data

DUSP19

Name: dual specificity phosphatase 19
Type: protein-coding
Aliases: DUSP17, LMWDSP3, SKRP1, TS-DSP1

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].

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