DUSP7
Sign in to saveAlso known as MKPX, PYST2, dual specificity phosphatase 7
Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.
Gene data
DUSP7- Name
- dual specificity phosphatase 7
- Type
- protein-coding
- Aliases
- MKPX, PYST2
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].
via MyGene.info
Gene · Ensembl
dual specificity phosphatase 7
- Symbol
- DUSP7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:52,048,919-52,056,577
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1468
- exact match
- identifiers.org/ncbigene/1849
- genomic end
- 52056571
- genomic start
- 52082935
- cytogenetic location
- 3p21.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- References
- Further reading
- External links
Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.
== Function ==