CLSPN

Name

claspin

Type

protein-coding

Position

35,720,218–35,770,002 (−)

Ensembl

ENSG00000092853

RefSeq RNA

NM_001190481.2, NM_001330490.2, NM_022111.4

RefSeq protein

NP_001177410.1, NP_001317419.1, NP_071394.2

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].