CLDN12
Sign in to saveAlso known as claudin 12
Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins.
In the Vinony graph
Within Vinony's link graph, CLDN12 is referenced by 2 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 7.
Its subject is documented across 7 Wikipedia language editions.
Gene data
CLDN12- Name
- claudin 12
- Type
- protein-coding
- Position
- 90,383,721–90,513,402 (+)
- Ensembl
- ENSG00000157224
- RefSeq RNA
- NM_001185072.3, NM_001185073.3, NM_012129.5
- RefSeq protein
- NP_001172001.1, NP_001172002.1, NP_036261.1
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
claudin 12
- Symbol
- CLDN12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:90,383,721-90,513,402
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 7 more facts
- HomoloGene ID
- 40809
- genomic end
- 90513402
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9069
- genomic start
- 90013035
- chromosome
- human chromosome 7
- cytogenetic location
- 7q21.13
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins.
==References==
Excerpted from Wikipedia’s “CLDN12” article, available under the CC BY-SA 4.0 licence.