DUSP1
Sign in to saveAlso known as CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.
Gene data
DUSP1- Name
- dual specificity phosphatase 1
- Type
- protein-coding
- Position
- 172,766,992–172,771,198 (−)
- Aliases
- CL100, HVH1, MKP-1, MKP1, PTPN10
- Ensembl
- ENSG00000120129
- RefSeq RNA
- NM_004417.4
- RefSeq protein
- NP_004408.1
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dual specificity phosphatase 1
- Symbol
- DUSP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:172,766,992-172,771,198
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3254
- exact match
- identifiers.org/ncbigene/1843
- genomic end
- 172198198
- genomic start
- 172768096
- cytogenetic location
- 5q35.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.
== Function ==