clocortolone
Sign in to saveAlso known as 9-chloro-6alpha-Fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione, 9-chloro-6alpha-Fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione, Clocortolon, Clocortolona, Clocortolonum
Clocortolone (Cloderm) is a topical steroid. It is used in the form of an ester, clocortolone pivalate, and applied as a cream. It is used for the treatment of dermatitis and is considered a medium-strength corticosteroid. It is unusual among steroids in that it contains a chlorine atom and a fluorine atom.
Research
27 papers- Clocortolone Pivalate.2006
- Safety and efficacy of clocortolone pivalate 0.1 percent cream in the treatment of atopic dermatitis, contact dermatitis, and seborrheic dermatitis.Cutis · 1981
- Clocortolone pivalate: a topical corticosteroid with a unique structure.Journal of drugs in dermatology : JDD · 2013
- Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review.Clinical, cosmetic and investigational dermatology · 2012
- Adherence to clocortolone pivalate cream 0.1% in a pediatric population with atopic dermatitis.Cutis · 2008
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 410.1660152759999
- Has use
- medication
Show 6 more facts
- medical condition treated
- inflammation
- chemical formula
- C₂₂H₂₈ClFO₄
- subject has role
- glucocorticoid
- isomeric SMILES
- [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
- NCI Thesaurus ID
- C61684
- canonical SMILES
- CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1C(=O)CO
Sources (2)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Pharmacology
- Cream vehicle
- Clinical studies
- Regulation history
- Commercialization
- Manufacturing process
- Commercialization history
- Price listing
- See also
- References
Clocortolone (Cloderm) is a topical steroid. It is used in the form of an ester, clocortolone pivalate, and applied as a cream. It is used for the treatment of dermatitis and is considered a medium-strength corticosteroid. It is unusual among steroids in that it contains a chlorine atom and a fluorine atom.
== Pharmacology == Clocortolone is an upper-mid potency topical corticosteroid formulation. It is rated at a class 4 potency on a scale of 1 (highest potency) to 7 (lowest potency). Most patients are treated with mid-potency topical corticosteroids, for they are an effective medium between safety and efficacy for short and long-term conditions.
Excerpted from Wikipedia’s “clocortolone” article, available under the CC BY-SA 4.0 licence.
Available in 7 languages
via Wikidata sitelinks · CC0