clorotepine

Clorotepine (; brand names Clotepin, Clopiben), also known as octoclothepin or octoclothepine, is an antipsychotic of the tricyclic group which was derived from perathiepin in 1965 and marketed in the Czech Republic by Spofa in or around 1971 for the treatment of schizophrenic psychosis.

In the Vinony graph

Vinony's link graph records 1,799 inbound references to clorotepine, and connects out to propranolol, fluphenazine and zuclopenthixol.

It is catalogued under topics including 4-Methylpiperazin-1-yl compounds, Antipsychotics and Chemical pages without DrugBank identifier.

Vinony links it to 6 Wikipedia language editions.

Chemical data

Formula: C19H21ClN2S
Molecular weight: 344.9 g/mol
IUPAC name: 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine
SMILES: CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
InChIKey: XRYLGRGAWQSVQW-UHFFFAOYSA-N
XLogP: 4.3
Polar surface area: 31.8 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 344.111

Show 3 more facts

chemical formula: C₁₉H₂₁ClN₂S
canonical SMILES: CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
Commons category: Clorotepine

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

See also
References

Clorotepine is known to have high affinity for the dopamine D1, D2, D3, and D4 receptors, the serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, and 5-HT7 receptors, the α1A-, α1B-, and α1D-adrenergic receptors, and the histamine H1 receptors, where it has been it has been confirmed to act as an antagonist (or inverse agonist) at most sites (and likely is as such at all of them based on structure–activity relationships), and it also blocks the reuptake of norepinephrine via inhibition of the norepinephrine transporter.

Excerpted from Wikipedia’s “clorotepine” article, available under the CC BY-SA 4.0 licence.