dactolisib

Also known as BEZ235, NVP-BEZ235, BEZ-235, NVP-BEZ 235, NVP BEZ235, NVPBEZ235, BEZ 235

Dactolisib (codenamed NVP-BEZ235 and BEZ-235, also known as RTB101) is an imidazoquinoline derivative acting as a PI3K inhibitor. It also inhibits mTOR. It is being investigated as a possible cancer treatment.

Research

498 papers

Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys.Journal of controlled release : official journal of the Controlled Release Society · 2019
Synergistic effect of Dactolisib/Lys05 combination on autophagy in A549 cells.Acta biochimica Polonica · 2023
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.BMC cancer · 2016
PI3K/mTOR Inhibitor Dactolisib Attenuates Allergic Response Through Inhibitions of the Sensitization and Mast Cell Activation.Die Pharmazie · 2023
Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations.Scientific reports · 2024

via PubMed

Wikidata facts

Mass: 469.19026

Show 4 more facts

chemical formula: C₃₀H₂₃N₅O
canonical SMILES: CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
World Health Organisation international non-proprietary name: dactolisib
Commons category: Dactolisib

Sources (3)

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References

{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 458976997 | ImageFile = Dactolisib.svg | ImageClass = skin-invert-image | ImageSize = 220px | ImageFile1 = Dactolisib molecule ball.png | ImageClass1 = bg-transparent | ImageSize1 = 240 | ImageAlt1 = Ball-and-stick model of the BEZ235 molecule | PIN = 2-Methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile | OtherNames = NVP-BEZ235; BEZ-235; RTB101

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