Structure via PubChem · Public domain (PubChem)
DADLE
Sign in to saveAlso known as [D-Ala2, D-Leu5]-enkephalin, DADL, leucine enkephalin-2-alanine, 2-D-alanine-5-D-leucine-enkephalin
composé chimique
In the Vinony graph
Within Vinony's link graph, DADLE is referenced by 694 other articles, and connects out to (+)-catechin, butorphanol and OPRM1.
It is catalogued under topics including Chembox image size set, Delta-opioid receptor agonists and ECHA InfoCard ID from Wikidata.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C29H39N5O7
- Molecular weight
- 569.6 g/mol
- IUPAC name
- (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
- SMILES
- C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
- InChIKey
- ZHUJMSMQIPIPTF-IBURTVSXSA-N
- XLogP
- -1.9
- Polar surface area
- 200 Ų
- H-bond donors
- 7
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Protein
via ChEMBL · EBI
Research
1,800 papers- DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury.British journal of pharmacology · 2024
- [D-Ala2, D-Leu5]-enkephalin (DADLE) provides protection against myocardial ischemia reperfusion injury by inhibiting Wnt/β-Catenin pathway.BMC cardiovascular disorders · 2024
- Multifaceted Effects of Delta Opioid Receptors and DADLE in Diseases of the Nervous System.Current drug discovery technologies · 2018
- DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway.Molecular medicine reports · 2017
- DADLE induces a reversible hibernation-like state in HeLa cells.Histochemistry and cell biology · 2006
via PubMed
Wikidata facts
- Mass
- 569.284949
Show 3 more facts
- chemical formula
- C₂₉H₃₉N₅O₇
- canonical SMILES
- CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N
- isomeric SMILES
- C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
Sources (2)
via Wikidata · CC0
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