DGUOK
Sign in to saveAlso known as deoxyguanosine kinase, MTDPS3, dGK, NCPH, PEOB4, NCPH1
Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.
Gene data
DGUOK- Name
- deoxyguanosine kinase
- Type
- protein-coding
- Aliases
- MTDPS3, NCPH, NCPH1, PEOB4, dGK
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
deoxyguanosine kinase
- Symbol
- DGUOK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:73,926,794-73,958,961
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DGUOK PDB 2ocp.png
Show 6 more facts
- HomoloGene ID
- 8456
- Commons category
- Deoxyguanosine kinase
- genomic start
- 74153953
- exact match
- identifiers.org/ncbigene/1716
- genomic end
- 74186088
- cytogenetic location
- 2p13.1
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Clinical
- References
- Further reading
- External links
Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.
== Function ==