DGUOK

Also known as deoxyguanosine kinase, MTDPS3, dGK, NCPH, PEOB4, NCPH1

Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.

In the Vinony graph

Within Vinony's link graph, DGUOK is referenced by 6 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DGUOK

Name: deoxyguanosine kinase
Type: protein-coding
Position: 73,926,794–73,958,961 (+)
Aliases: MTDPS3, NCPH, NCPH1, PEOB4, dGK
Ensembl: ENSG00000114956
RefSeq RNA: NM_001318859.2, NM_001318860.2, NM_001318861.2, NM_001318862.2, NM_001318863.2
RefSeq protein: NP_001305788.1, NP_001305789.1, NP_001305790.1, NP_001305791.1, NP_001305792.1

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].