diflorasone

Also known as (6α,11β,16β)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, Diflorasonum, (6alpha,11beta,16beta)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, Diflorasona

Diflorasone is a synthetic glucocorticoid corticosteroid which was never marketed. A diacetate ester of diflorasone, diflorasone diacetate, in contrast, has been marketed.

In the Vinony graph

Vinony's link graph records 271 inbound references to diflorasone, and connects out to mometasone furoate, fludrocortisone and ulipristal acetate.

It sits within the topics Abandoned drugs, Chemical pages without DrugBank identifier and Diketones.

Vinony links it to 6 Wikipedia language editions.

Chemical data

Formula: C22H28F2O5
Molecular weight: 410.5 g/mol
IUPAC name: (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
SMILES: C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F
InChIKey: WXURHACBFYSXBI-XHIJKXOTSA-N
XLogP: 1.9
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 7
Formal charge: 0

via PubChem

Research

54 papers

Diflorasone.2006
Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid.The Journal of international medical research · 1976
Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis.Dermatology (Basel, Switzerland) · 1993
Structures from powders: diflorasone diacetate.Steroids · 2009
Liquid chromatographic assay for diflorasone diacetate in cream and ointment formulations.Journal of pharmaceutical sciences · 1984

via PubMed

Wikidata facts

Mass: 410.19
Has use: medication

Show 7 more facts

chemical formula: C₂₂H₂₈F₂O₅
medical condition treated: inflammation
canonical SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F
isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F
World Health Organisation international non-proprietary name: diflorasone
subject has role: glucocorticoid
stereoisomer of: flumetasone

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Encyclopedic overview

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Contents

References

Diflorasone is a synthetic glucocorticoid corticosteroid which was never marketed. A diacetate ester of diflorasone, diflorasone diacetate, in contrast, has been marketed.

==References==

Excerpted from Wikipedia’s “diflorasone” article, available under the CC BY-SA 4.0 licence.