dimetacrine

Also known as 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine

Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.

In the Vinony graph

Vinony's link graph records 426 inbound references to dimetacrine, and connects out to propranolol, N-methylserotonin and atropine.

It sits within the topics Dimethylamino compounds, Drugs with non-standard legal status and Tricyclic antidepressants.

Vinony links it to 8 Wikipedia language editions.

Wikidata facts

Mass: 294.209599

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chemical formula: C₂₀H₂₆N₂
World Health Organisation international non-proprietary name: dimetacrine
canonical SMILES: CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C
defined daily dose: 0.15
Commons category: Dimetacrine

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Encyclopedic overview

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Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

Excerpted from Wikipedia’s “dimetacrine” article, available under the CC BY-SA 4.0 licence.