EI24
Sign in to saveAlso known as EPG4, PIG8, TP53I8, EI24, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.
Gene data
EI24- Name
- EI24 autophagy associated transmembrane protein
- Type
- protein-coding
- Aliases
- EPG4, PIG8, TP53I8
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014].
via MyGene.info
Gene · Ensembl
EI24 autophagy associated transmembrane protein
- Symbol
- EI24
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:125,536,608-125,585,035
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3588
- exact match
- identifiers.org/ncbigene/9538
- genomic start
- 125569280
- genomic end
- 125584684
- cytogenetic location
- 11q24.2
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.