ENDOG
Sign in to saveAlso known as endonuclease G
Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress. As a result, EndoG has been implicated in cancer, aging, and neurodegenerative diseases such as Parkinson's disease (PD). Regulation of its expression levels thus holds potential to treat or ameliorate those conditions.
Gene data
ENDOG- Name
- endonuclease G
- Type
- protein-coding
- Position
- 128,818,451–128,822,683 (+)
- Ensembl
- ENSG00000167136
- RefSeq RNA
- NM_004435.2, XM_011518347.3, XM_054362256.1
- RefSeq protein
- NP_004426.2, XP_011516649.2, XP_054218231.1
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
endonuclease G
- Symbol
- ENDOG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:128,818,451-128,822,683
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- exact match
- identifiers.org/ncbigene/2021
- found in taxon
- Homo sapiens
- HomoloGene ID
- 55823
- genomic end
- 128822676
- genomic start
- 128818500
- chromosome
- human chromosome 9
- cytogenetic location
- 9q34.11
Sources (4)
via Wikidata · CC0
~8 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- References
- Further reading
Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress. As a result, EndoG has been implicated in cancer, aging, and neurodegenerative diseases such as Parkinson's disease (PD). Regulation of its expression levels thus holds potential to treat or ameliorate those conditions.
== Structure ==
Excerpted from Wikipedia’s “ENDOG” article, available under the CC BY-SA 4.0 licence.