Structure via PubChem · Public domain (PubChem)
ethacizine
Sign in to saveAlso known as Diaethylaminopropyonylaethoxycarbonylaminophenothiazinum, Аеthacizinum, Ethacizinum
Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome.
Chemical data
- Formula
- C22H27N3O3S
- Molecular weight
- 413.5 g/mol
- IUPAC name
- ethyl N-[10-[3-(diethylamino)propanoyl]phenothiazin-2-yl]carbamate
- SMILES
- CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=C1C=C(C=C3)NC(=O)OCC
- InChIKey
- PQXGNJKJMFUPPM-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 87.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
- Indications
- cardiac arrhythmia
via ChEMBL · EBI
Research
161 papers- Antiarrhythmic efficacy of ethacizine assessed by programmed electrical stimulation in patients with ventricular tachycardia.Pacing and clinical electrophysiology : PACE · 1992
- [Ethacizine in the treatment of psoriasis].Vestnik dermatologii i venerologii · 1989
- Moracizine and ethacizine effects on membrane receptors.Arzneimittel-Forschung · 1989
- [Comparative evaluation of the effects of ethacizine and Bonnecor in the treatment of supraventricular paroxysmal tachycardia].Kardiologiia · 1991
- [Electrophysiological effects of ethacizine in experimental myocardial infarction and stimulation of sympathetic heart innervation].Eksperimental'naia i klinicheskaia farmakologiia · 2002
via PubMed
Wikidata facts
- Mass
- 413.177
- Has use
- medication
Show 4 more facts
- canonical SMILES
- CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=C1C=C(C=C3)NC(=O)OCC
- chemical formula
- C₂₂H₂₇N₃O₃S
- subject has role
- antiarrhythmic agent
- medical condition treated
- heart arrhythmia
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome.
It is manufactured under the brand name Ethacizin (Этацизин) by Latvian pharmaceutical company Olainfarm. ==Synthesis== For the treatment of heart infarction: thumb|center|501px|Synthesis: Patent:
Excerpted from Wikipedia’s “ethacizine” article, available under the CC BY-SA 4.0 licence.
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