EXOC7

Also known as 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, BLOM4

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

Gene data

EXOC7

Name: exocyst complex component 7
Type: protein-coding
Position: 76,080,995–76,121,576 (−)
Aliases: 2-5-3p, BLOM4, EX070, EXO70, Exo70p, NEDSEBA, YJL085W
Ensembl: ENSG00000182473
RefSeq RNA: NM_001013839.4, NM_001145297.4, NM_001145298.4, NM_001145299.4, NM_001282313.2
RefSeq protein: NP_001013861.1, NP_001138769.1, NP_001138770.1, NP_001138771.1, NP_001269242.1

The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].

Gene Ontology

Biological process

mitotic cytokinesis exocytosis exocytosis vesicle docking involved in exocytosis regulation of macroautophagy membrane fission vesicle tethering involved in exocytosis positive regulation of mitotic cytokinetic process

Molecular function

protein binding phosphatidylinositol-4,5-bisphosphate binding protein-macromolecule adaptor activity

Cellular component

exocyst exocyst microtubule organizing center cytosol cytosol plasma membrane plasma membrane membrane

Pathways

Insulin signaling pathway - Homo sapiens (human)Salmonella infection - Homo sapiens (human)Translocation of SLC2A4 (GLUT4) to the plasma membrane Organelle biogenesis and maintenance Membrane Trafficking Insulin processing Peptide hormone metabolism Metabolism of proteins Cilium Assembly VxPx cargo-targeting to cilium

via MyGene.info

Gene · Ensembl

exocyst complex component 7

Symbol: EXOC7
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:76,080,995-76,121,576
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein EXOC7 PDB 2pft.png

Show 5 more facts

HomoloGene ID: 41019
exact match: identifiers.org/ncbigene/23265
genomic end: 74117657
genomic start: 76081016
cytogenetic location: 17q25.1

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Further reading

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae, this and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast. It interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.