Structure via PubChem · Public domain (PubChem)
فبوکسوستات
Sign in to saveAlso known as Adenuric®, MX-67, Tei 6720, Tei-6720, TMX 67, Uloric®, Fébuxostat, Febuxostatum
Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. It is generally recommended only for people who cannot take allopurinol. It is taken by mouth.
Chemical data
- Formula
- C16H16N2O3S
- Molecular weight
- 316.4 g/mol
- IUPAC name
- 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
- SMILES
- CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
- InChIKey
- BQSJTQLCZDPROO-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 111 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- oral
- Indications
- gout, cardiovascular disease, hypertension, angina pectoris
via ChEMBL · EBI
Research
1,660 papers- Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial.Lancet (London, England) · 2020
- Febuxostat compared with allopurinol in patients with hyperuricemia and gout.The New England journal of medicine · 2005
- Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double-Blind, Phase 3 Trial in China.Arthritis & rheumatology (Hoboken, N.J.) · 2025
- Febuxostat provides renoprotection in patients with hyperuricemia or gout: a systematic review and meta-analysis of randomized controlled trials.Annals of medicine · 2024
- The role of febuxostat in gout.Current opinion in rheumatology · 2019
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 316.088
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₆H₁₆N₂O₃S
- Commons category
- Febuxostat
- canonical SMILES
- CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
- subject has role
- xanthine oxidase inhibitor
- medical condition treated
- gout
- legal status (medicine)
- boxed warning
- defined daily dose
- 80
Sources (6)
via Wikidata · CC0