FLRT2
Sign in to saveAlso known as fibronectin leucine rich transmembrane protein 2
Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.
In the Vinony graph
Within Vinony's link graph, FLRT2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
FLRT2- Name
- fibronectin leucine rich transmembrane protein 2
- Type
- protein-coding
- Position
- 85,530,017–85,654,428 (+)
- Ensembl
- ENSG00000185070
- RefSeq RNA
- NM_001346143.2, NM_001346144.2, NM_001346145.2, NM_001346146.2, NM_013231.6
- RefSeq protein
- NP_001333072.1, NP_001333073.1, NP_001333074.1, NP_001333075.1, NP_037363.1
This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
fibronectin leucine rich transmembrane protein 2
- Symbol
- FLRT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:85,530,017-85,654,428
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 8291
- exact match
- identifiers.org/ncbigene/23768
- genomic end
- 85654428
- genomic start
- 85996488
- chromosome
- human chromosome 14
- cytogenetic location
- 14q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.
== Function ==
Excerpted from Wikipedia’s “FLRT2” article, available under the CC BY-SA 4.0 licence.