Structure via PubChem · Public domain (PubChem)
formoterol
Sign in to saveAlso known as FOR258, BD-40A, CGP-25827A, Foradil®, Oxeze/Oxis®, YM-08316, 2'-hydroxy-5'-{1-hydroxy-2-[(p-methoxy-alpha-methylphenethyl)amino]ethyl}formanilide, N-[2-hydroxy-5-(1-hydroxy-2-{[2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl)phenyl]formamide
Formoterol, also known as eformoterol, is a long-acting β2 agonist (LABA) used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease (COPD). Formoterol has an extended duration of action (up to 12 h) compared to short-acting β2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h. Formoterol has a relatively rapid onset of action compared to other LABAs, and is effective within 2-3 minutes. The 2022 Global Initiative for Asthma report recommends a combination formoterol/inhaled corticosteroid inhaler as both a preve
Key facts
- Drug.verifiedrevid
- 461113044
- Drug.caption2
- Above (R,R)-(−)-formoterol Below (S,S)-(+)-formoterol
- Drug.image
- Formoterol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 230
- Drug.image2
- Formoterol ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.caption
- Formoterol molecular structure
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Oxeze, Foradil, Symbicort, others
- Drug.pregnancy_AU
- B3
- Drug.licence_EU
- yes
- Drug.INN_EMA
- formoterol fumarate dihydrate
- Drug.legal_AU
- S4
- Drug.legal_NZ
- Prescription only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C19H24N2O4
- Molecular weight
- 344.4 g/mol
- IUPAC name
- N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
- SMILES
- CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
- InChIKey
- BPZSYCZIITTYBL-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 90.8 Ų
- H-bond donors
- 4
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 344.173607
Show 4 more facts
- chemical formula
- C₁₉H₂₄N₂O₄
- World Health Organisation international non-proprietary name
- formoterol
- canonical SMILES
- CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
- Commons category
- Formoterol
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- Side effects
- Mechanism of action
- Society and culture
- Brand names
- Uses and combinations
- References
Formoterol, also known as eformoterol, is a long-acting β2 agonist (LABA) used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease (COPD). Formoterol has an extended duration of action (up to 12 h) compared to short-acting β2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h. Formoterol has a relatively rapid onset of action compared to other LABAs, and is effective within 2-3 minutes. The 2022 Global Initiative for Asthma report recommends a combination formoterol/inhaled corticosteroid inhaler as both a preventer and reliever treatment for asthma in adults. In children, a short-acting β2 adrenergic agonist (e.g., salbutamol) is still recommended.
It was patented in 1972 and came into medical use in 1998. It is available as a generic medication. It is also marketed in the combination formulations budesonide/formoterol and mometasone/formoterol.