FZD2

Also known as Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Gene data

FZD2

Name: frizzled class receptor 2
Type: protein-coding
Position: 44,557,484–44,561,262 (+)
Aliases: Fz2, OMOD2, fz-2, fzE2, hFz2
Ensembl: ENSG00000180340
RefSeq RNA: NM_001466.4
RefSeq protein: NP_001457.1

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

cell surface receptor signaling pathway

Article

3 sections

Contents

References
Further reading
External links

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.