globoside
Sign in to saveAlso known as globosides
thumb|right|120px|N-Acetylgalactosamine|N-Acetylgalactosamine thumb|Sphingosine Globosides (also known as globo-series glycosphingolipids) are a sub-class of the lipid class glycosphingolipid with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. One characteristic of globosides is that the "core" sugars consists of Glucose-Galactose-Galactose (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another i
Research
934 papers- Globoside Is an Essential Intracellular Factor Required for Parvovirus B19 Endosomal Escape.Cells · 2024
- Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier.PLoS pathogens · 2023
- Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection.Journal of virology · 2019
- Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.Frontiers in immunology · 2022
- Globoside accelerates the differentiation of dental epithelial cells into ameloblasts.International journal of oral science · 2016
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Article
4 sectionsContents
- Globoside-4 (Gb4)
- Globoside-5 (Gb5)
- References
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thumb|right|120px|N-Acetylgalactosamine|N-Acetylgalactosamine thumb|Sphingosine Globosides (also known as globo-series glycosphingolipids) are a sub-class of the lipid class glycosphingolipid with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. One characteristic of globosides is that the "core" sugars consists of Glucose-Galactose-Galactose (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another important characteristic of globosides is that they are neutral at pH 7, because they usually do not contain neuraminic acid, a sugar with an acidic carboxy-group. However, some globosides with the core structure Cer-Glc-Gal-Gal do contain neuraminic acid, e.g. the globo-series glycosphingolipid "SSEA-4-antigen".
The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.