globoside
Sign in to saveAlso known as globosides
thumb|right|120px|N-Acetylgalactosamine|N-Acetylgalactosamine thumb|Sphingosine Globosides (also known as globo-series glycosphingolipids) are a sub-class of the lipid class glycosphingolipid with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. One characteristic of globosides is that the "core" sugars consists of Glucose-Galactose-Galactose (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another i
In the Vinony graph
Vinony's link graph records 187 inbound references to globoside, and connects out to blood transfusion, sugar and virus.
It sits within the topics Blood antigen systems, Commons link from Wikidata and Glycolipids.
Vinony links it to 15 Wikipedia language editions.
Research
934 papers- Globoside Is an Essential Intracellular Factor Required for Parvovirus B19 Endosomal Escape.Cells · 2024
- Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier.PLoS pathogens · 2023
- Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection.Journal of virology · 2019
- Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.Frontiers in immunology · 2022
- Globoside accelerates the differentiation of dental epithelial cells into ameloblasts.International journal of oral science · 2016
via PubMed
Wikidata facts
- Subclass of
- glycosphingolipid
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- Commons gallery
- Globósido
- Commons category
- Globoside
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Globoside-4 (Gb4)
- Globoside-5 (Gb5)
- References
- External links
thumb|right|120px|N-Acetylgalactosamine|N-Acetylgalactosamine thumb|Sphingosine Globosides (also known as globo-series glycosphingolipids) are a sub-class of the lipid class glycosphingolipid with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. One characteristic of globosides is that the "core" sugars consists of Glucose-Galactose-Galactose (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another important characteristic of globosides is that they are neutral at pH 7, because they usually do not contain neuraminic acid, a sugar with an acidic carboxy-group. However, some globosides with the core structure Cer-Glc-Gal-Gal do contain neuraminic acid, e.g. the globo-series glycosphingolipid "SSEA-4-antigen".
The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.
Excerpted from Wikipedia’s “globoside” article, available under the CC BY-SA 4.0 licence.