SEMA7A
Sign in to saveAlso known as CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group)
Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.
Gene data
SEMA7A- Name
- semaphorin 7A (JohnMiltonHagen blood group)
- Type
- protein-coding
- Position
- 74,409,289–74,433,965 (−)
- Aliases
- CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, PFIC11, SEMAK1, SEMAL
- Ensembl
- ENSG00000138623
- RefSeq RNA
- NM_001146029.3, NM_001146030.3, NM_003612.5, XM_047433177.1, XM_054332566.1
- RefSeq protein
- NP_001139501.1, NP_001139502.1, NP_003603.1, XP_047289133.1, XP_054188541.1
This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
semaphorin 7A (JohnMiltonHagen blood group)
- Symbol
- SEMA7A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:74,409,289-74,433,965
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- SEMA7A.png
Show 7 more facts
- HomoloGene ID
- 2678
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8482
- genomic end
- 74433958
- genomic start
- 74701630
- chromosome
- human chromosome 15
- cytogenetic location
- 15q24.1
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
9 sectionsContents
- Development
- Tumorigenesis
- Genetics
- Molecular biology
- Notes
- See also
- References
- Further reading
- External links
Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.
SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM] SEMA7A is expressed in various adult tissues such as adipose, colon, esophagus, heart, brain, spleen, testis, lung, ovary, and uterus.
Excerpted from Wikipedia’s “SEMA7A” article, available under the CC BY-SA 4.0 licence.