SEMA7A

Also known as CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group)

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.

Gene data

SEMA7A

Name: semaphorin 7A (JohnMiltonHagen blood group)
Type: protein-coding
Aliases: CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, PFIC11, SEMAK1, SEMAL

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

via MyGene.info

Gene · Ensembl

semaphorin 7A (JohnMiltonHagen blood group)

Symbol: SEMA7A
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:74,409,289-74,433,965
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: SEMA7A.png

Show 5 more facts

HomoloGene ID: 2678
exact match: identifiers.org/ncbigene/8482
genomic end: 74433958
genomic start: 74701630
cytogenetic location: 15q24.1

Sources (3)

via Wikidata · CC0

~3 min read

Article

9 sections

Contents

Development
Tumorigenesis
Genetics
Molecular biology
Notes
See also
References
Further reading
External links

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM] SEMA7A is expressed in various adult tissues such as adipose, colon, esophagus, heart, brain, spleen, testis, lung, ovary, and uterus.