GPR15
Sign in to saveAlso known as BOB, G protein-coupled receptor 15
G protein-coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene.
Gene data
GPR15- Name
- G protein-coupled receptor 15
- Type
- protein-coding
- Aliases
- BOB
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012].
via MyGene.info
Gene · Ensembl
G protein-coupled receptor 15
- Symbol
- GPR15
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:98,531,978-98,534,681
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3869
- exact match
- identifiers.org/ncbigene/2838
- genomic end
- 98534681
- genomic start
- 98531978
- cytogenetic location
- 3q11.2
Sources (4)
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Tissue distribution
- Function
- Ligands
- Clinical significance
- Lifestyle
- References
- Further reading
G protein-coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene.
GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein, GPCR). The GPR15 gene is localized at chromosome 3q11.2-q13.1. It is found in epithelial cells, synovial macrophages, endothelial cells and lymphocytes especially T cells. From the mRNA sequence a 40.8 kD molecular weight of GPR15 is proposed. In an epithelial tumour cell line (HT-29), however, a 36 kD band, composed of GPR15 and galactosyl ceramide, was detected. Protein expression in lymphocytes is strongly associated with hypomethylation of its gene.