HAPLN2
Sign in to saveAlso known as BRAL1, hyaluronan and proteoglycan link protein 2
Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene. HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.
Gene data
HAPLN2- Name
- hyaluronan and proteoglycan link protein 2
- Type
- protein-coding
- Position
- 156,619,331–156,626,590 (+)
- Aliases
- BRAL1
- Ensembl
- ENSG00000132702
- RefSeq RNA
- NM_021817.3, XM_011509853.3, XM_017002020.2, XM_047427123.1, XM_054332854.1
- RefSeq protein
- NP_068589.1, XP_011508155.1, XP_016857509.1, XP_047283079.1, XP_054188829.1
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
hyaluronan and proteoglycan link protein 2
- Symbol
- HAPLN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:156,619,331-156,626,590
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 11045
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/60484
- genomic end
- 156595517
- genomic start
- 156619331
- chromosome
- human chromosome 1
- cytogenetic location
- 1q23.1
- expressed in
- inferior olivary nucleus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene. HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.
== Function == Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal.
Excerpted from Wikipedia’s “HAPLN2” article, available under the CC BY-SA 4.0 licence.