IL17A

Name

interleukin 17A

Type

protein-coding

Position

52,186,375–52,190,638 (+)

Aliases

CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17

Ensembl

ENSG00000112115

RefSeq RNA

NM_002190.3

RefSeq protein

NP_002181.1

This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020].

via MyGene.info

Gene · Ensembl

interleukin 17A

Symbol

IL17A

Biotype

Protein coding

Organism

Homo sapiens

Location

6:52,186,375-52,190,638

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0