imidapril

Key facts

Drug.N

3

Drug.O

6

Drug.melting_point

139

Drug.melting_high

140

Drug.Verifiedfields

changed

Drug.Watchedfields

changed

Drug.verifiedrevid

444377257

Drug.image

Imidapril.svg

Drug.image_class

skin-invert-image

Drug.tradename

Tanatril, others

Drug.routes_of_administration

By mouth

Drug.ATC_prefix

C09

Drug.ATC_suffix

AA16

Drug.legal_CA

Rx-only

Drug.legal_status

Rx-only

Drug.bioavailability

42% (imidaprilat)

Drug.protein_bound

85% (imidapril),53% (imidaprilat)

Drug.metabolites

Imidaprilat (active metabolite)

via Wikipedia infobox

Chemical data

Formula

C20H27N3O6

Molecular weight

405.4 g/mol

IUPAC name

(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid

SMILES

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@@H](CN(C2=O)C)C(=O)O

InChIKey

KLZWOWYOHUKJIG-BPUTZDHNSA-N

XLogP

-0.7

Polar surface area

116 Ų

H-bond donors

2

H-bond acceptors

7

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1993

Admin. routes

oral

Indications

cardiovascular disease, Autosomal dominant polycystic kidney disease, essential hypertension

via ChEMBL · EBI

• Imidapril.2006
• Imidapril in heart failure.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2006
• Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor.Cardiovascular drug reviews · 2002
• Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure.Drugs · 2007
• Imidapril-induced eosinophilic pleurisy. Case report and review of the literature.Respiration; international review of thoracic diseases · 2005

via PubMed

Wikidata facts

Subclass of

carboxylic acid

Mass

405.189986

Has use

medication

via Wikidata · CC0