Interleukin 2
Sign in to saveAlso known as involved in regulation of T-cell clonal expansion, T-cell growth factor, IL2, interleukin-2, T cell growth factor, TCGF
mammalian protein found in Homo sapiens
Protein · UniProt
Interleukin-2
- Gene
- IL2
- Organism
- Homo sapiens (Human)
- Length
- 153 aa
- Molecular mass
- 17,628 Da
- Evidence
- 1: Evidence at protein level
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) (PubMed:16293754, PubMed:16477002). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylatio…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
464 registered- EARLY_PHASE1RECRUITINGTreatment of Refractory cGVHD by Donor-derived Treg Cell Injection Combined With Recombinant Human Interleukin-2Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · NCT06920199
- NAWITHDRAWNA Randomized Trial of L-735,524, An Inhibitor of the HIV Protease Enzyme, and Interleukin-2 in Persons Infected With HIV (NOTE: Only For Patients Who Previously Completed NIAID 93 CC-113)National Institute of Allergy and Infectious Diseases (NIAID) · NCT00000804
- NACOMPLETEDA Study to Evaluate the Ability of TNFR:Fc to Decrease the Amount of IL-6 (Interleukin-6) and TNF-alpha (Tumor Necrosis Factor) in HIV-Infected PatientsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001116
- PHASE3COMPLETEDInterleukin-2 or Observation Following Radiation Therapy, Combination Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's LymphomaNational Cancer Institute (NCI) · NCT00002649
- PHASE3COMPLETEDA Study to Evaluate the Effects of Giving Proleukin (rIL-2) to HIV-Positive Patients With CD4 Counts Greater Than 300 Cells/mm3National Institute of Allergy and Infectious Diseases (NIAID) · NCT00000949
- PHASE2COMPLETEDCombination Chemotherapy Followed by Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Acute LeukemiaHerbert Irving Comprehensive Cancer Center · NCT00008190
Wikidata facts
- Image
- IL2 Crystal Structure.png
Show 1 more fact
- exact match
- purl.uniprot.org/uniprot/P60568
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