伊維菌素

抗寄生虫药物

OverviewAI-generated

Ivermectin is a chemical compound with the formula C₉₅H₁₄₆O₂₈. Its mass is 1736.2, and it has a defined daily dose of 12. The molecule possesses a topological polar surface area of 340, with 6 hydrogen bond donors and 28 hydrogen bond acceptors. It carries a charge of 0.

The compound is identified by the InChIKey SPBDXSGPUHCETR-JFUDTMANSA-N and the NCI Thesaurus ID C61796. It is associated with a PubChem CID of 9812710. A Commons category exists for ivermectin. The subject is referenced by 1,644 other encyclopedia articles and has a PubMed count of 11981.

Synthesized by Vinony from 15 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Chemical data

Formula: C95H146O28
Molecular weight: 1736.2 g/mol
IUPAC name: (1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
SMILES: CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)O[C@@H]1C(C)C
InChIKey: SPBDXSGPUHCETR-JFUDTMANSA-N
Polar surface area: 340 Å²
H-bond donors: 6
H-bond acceptors: 28
Formal charge: 0

via PubChem

Research

11,981 papers

Ivermectin, a potential anticancer drug derived from an antiparasitic drug.Pharmacological research · 2021
Ivermectin: a mini-review.Clinical toxicology (Philadelphia, Pa.) · 2022
Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?Current oncology reports · 2025
Ivermectin for preventing and treating COVID-19.The Cochrane database of systematic reviews · 2022
Ivermectin and non-parasitic disorders: An update.Current opinion in pharmacology · 2025

via PubMed

Wikidata facts

Subclass of: mixture
Mass: 1736.2
Image: Ivermectin skeletal.svg
Has use: medication

Show 9 more facts

canonical SMILES: CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C.CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)OC1C(C)C
chemical formula: C₉₅H₁₄₆O₂₈
World Health Organisation international non-proprietary name: ivermectin
medical condition treated: onchocerciasis
defined daily dose: 12
NCI Thesaurus ID: C61796
subject has role: essential medicine
described at URL: www.theatlantic.com/science/archive/2021/10/ivermectin-research-problems/620473/?utm_source=pocket-newtab-global-en-GB
Commons category: Ivermectin

Sources (7)

via Wikidata · CC0

Article · 中文

伊維菌素（英語：ivermectin）也稱為愛獲滅，是一種阿維菌素家族有效抗多種寄生蟲的治療藥物，其適用於治療頭蝨、疥蟎引起的疥瘡，蟠尾絲蟲症（河盲症），線蟲感染，班氏絲蟲感染導致的象皮病等。伊維菌素可以塗抹於皮膚或是口服，但應避免接觸眼睛常見的副作用包含眼睛紅癢，皮膚乾燥與灼燒感。目前尚不清楚在孕期中使用是否安全，但是在哺乳期使用似乎尚可。其作用機制是使增加無脊椎動物的細胞膜可透性，導致它們死亡。伊維菌素發現於1975年，並在1981年列為藥物。它是世界卫生组织基本药物标准清单中的一部份，是基層健康衛生系統中非常重要的藥物。一套治療流程需要的藥物售價約為0.12美金，在美國約要價25到50美金，在其他的動物身上，伊維菌素用於治療與預防犬心絲蟲等疾病。

Abstract from DBpedia / Wikipedia · CC BY-SA