KAT6A

Also known as MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220, MRD32, MYST-3, lysine acetyltransferase 6A

K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.

In the Vinony graph

Vinony's link graph records 8 inbound references to KAT6A, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 5 Wikipedia language editions.

Gene data

KAT6A

Name: lysine acetyltransferase 6A
Type: protein-coding
Position: 41,929,479–42,051,998 (−)
Aliases: ARTHS, MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220
Ensembl: ENSG00000083168
RefSeq RNA: NM_001099412.1, NM_001099413.1, NM_001305878.2, NM_006766.5
RefSeq protein: NP_001292807.1, NP_006757.2

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].

Pathways

Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Generic Transcription Pathway HATs acetylate histones Chromatin modifying enzymes Transcriptional Regulation by TP53 Chromatin organization Regulation of TP53 Activity Regulation of TP53 Activity through Acetylation RNA Polymerase II Transcription Gene expression (Transcription)

via MyGene.info

Gene · Ensembl

lysine acetyltransferase 6A

Symbol: KAT6A
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:41,929,479-42,051,998
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MYST3 PDB 1m36.png

Show 8 more facts

HomoloGene ID: 4924
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7994
genomic end: 42051994
genomic start: 41786997
chromosome: human chromosome 8
cytogenetic location: 8p11.21
expressed in: Vulva

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Protein function
Arboleda-Tham syndrome
References
Further reading

K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.

== Protein function ==

Excerpted from Wikipedia’s “KAT6A” article, available under the CC BY-SA 4.0 licence.