KERA

Also known as CNA2, KTN, SLRR2B, keratocan

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

Gene data

KERA

Name: keratocan
Type: protein-coding
Position: 91,050,491–91,058,024 (−)
Aliases: CNA2, KTN, SLRR2B
Ensembl: ENSG00000139330
RefSeq RNA: NM_007035.4
RefSeq protein: NP_008966.1

The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010].

Gene Ontology

Cellular component

extracellular region extracellular region Golgi lumen extracellular matrix lysosomal lumen lysosomal lumen gel phase of interstitial matrix

Pathways

Metabolism Glycosaminoglycan metabolism Keratan sulfate/keratin metabolism Disease Keratan sulfate biosynthesis Keratan sulfate degradation Diseases associated with glycosaminoglycan metabolism Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

via MyGene.info

Gene · Ensembl

keratocan

Symbol: KERA
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:91,050,491-91,058,024
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 5106
exact match: identifiers.org/ncbigene/11081
genomic end: 91058024
genomic start: 91444268
cytogenetic location: 12q21.33

Sources (4)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.