Kynureninase
Sign in to saveAlso known as KYNU, L-kynurenine hydrolase
Kynureninase or L-Kynurenine hydrolase (KYNU) () is a pyridoxal-phosphate dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid. It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.
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Vinony's link graph records 186 inbound references to Kynureninase, and connects out to mitochondrion, PubMed and PubMed Central.
It is catalogued under topics including EC 3.7.1 and Genes on human chromosome 2.
Vinony links it to 11 Wikipedia language editions.
Key facts
- Enzyme.Name
- kynureninase
- Enzyme.EC_number
- 3.7.1.3
- Enzyme.CAS_number
- 9024-78-6
- Enzyme.GO_code
- 0030429
- Enzyme.image
- Kynureninase2HZP.jpg
- Enzyme.caption
- Crystal structure of Homo sapiens kynureninase.
via Wikipedia infobox
Protein · UniProt
Kynureninase
- Gene
- KYNU
- Organism
- Homo sapiens (Human)
- Length
- 465 aa
- Molecular mass
- 52,352 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
- Image
- Kynureninase2HZP.jpg
Show 5 more facts
- Commons category
- Kynureninase
- P352
- Châtellenot
- cell component
- nucleoplasm
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/Q16719
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Function
- References
- Further reading
- External links
Kynureninase or L-Kynurenine hydrolase (KYNU) () is a pyridoxal-phosphate dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid. It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.
KYNU is part of the pathway for the catabolism of tryptophan and the biosynthesis of nicotinamide adenine dinucleotide (NAD) cofactors from tryptophan (Trp).
Excerpted from Wikipedia’s “Kynureninase” article, available under the CC BY-SA 4.0 licence.
Available in 11 languages
via Wikidata sitelinks · CC0