lafutidine

Lafutidine (INN) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to treat gastrointestinal disorders. It is marketed in South Korea, Japan and India.

Research

124 papers

Lafutidine-based triple therapy for Helicobacter pylori eradication.Hepato-gastroenterology · 2010
Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial.Scientific reports · 2025
Assessing lafutidine's potential to protect lung cancer patients from chemotherapy-induced neuropathy.Annals of palliative medicine · 2024
Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota.Pharmacology · 2023
[Pharmacological and therapeutic properties of lafutidine (stogar and protecadin), a novel histamine H2 receptor antagonist with gastroprotective activity].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 2001

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Wikidata facts

Mass: 431.188

Show 5 more facts

isomeric SMILES: C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\CNC(=O)CS(=O)CC3=CC=CO3
chemical formula: C₂₂H₂₉N₃O₄S
canonical SMILES: C1CCN(CC1)CC2=CC(=NC=C2)OCC=CCNC(=O)CS(=O)CC3=CC=CO3
Commons category: Lafutidine
defined daily dose: 20

Sources (3)

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Article

5 sections

Contents

Medical use
Adverse effects
Mechanism of action
Trade names
References

==Medical use== Lafutidine is used to treat gastric ulcers, duodenal ulcers, as well as wounds in the lining of the stomach associated with acute gastritis and acute exacerbation of chronic gastritis.