Structure via PubChem · Public domain (PubChem)
lafutidine
Sign in to saveLafutidine (INN) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to treat gastrointestinal disorders. It is marketed in South Korea, Japan and India.
Chemical data
- Formula
- C22H29N3O4S
- Molecular weight
- 431.6 g/mol
- IUPAC name
- 2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[[4-(piperidin-1-ylmethyl)-2-pyridinyl]oxy]but-2-enyl]acetamide
- SMILES
- C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\CNC(=O)CS(=O)CC3=CC=CO3
- InChIKey
- KMZQAVXSMUKBPD-DJWKRKHSSA-N
- XLogP
- 1.4
- Polar surface area
- 104 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- gastroesophageal reflux disease, Peptic ulcer, chronic gastritis, gastric ulcer
via ChEMBL · EBI
Research
124 papers- Lafutidine-based triple therapy for Helicobacter pylori eradication.Hepato-gastroenterology · 2010
- Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial.Scientific reports · 2025
- Assessing lafutidine's potential to protect lung cancer patients from chemotherapy-induced neuropathy.Annals of palliative medicine · 2024
- Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota.Pharmacology · 2023
- [Pharmacological and therapeutic properties of lafutidine (stogar and protecadin), a novel histamine H2 receptor antagonist with gastroprotective activity].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 2001
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 431.188
Show 7 more facts
- isomeric SMILES
- C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\CNC(=O)CS(=O)CC3=CC=CO3
- chemical formula
- C₂₂H₂₉N₃O₄S
- canonical SMILES
- C1CCN(CC1)CC2=CC(=NC=C2)OCC=CCNC(=O)CS(=O)CC3=CC=CO3
- subject has role
- H2 antagonists
- has characteristic
- bitterness
- Commons category
- Lafutidine
- defined daily dose
- 20
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Medical use
- Adverse effects
- Mechanism of action
- Trade names
- References
Lafutidine (INN) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to treat gastrointestinal disorders. It is marketed in South Korea, Japan and India.
==Medical use== Lafutidine is used to treat gastric ulcers, duodenal ulcers, as well as wounds in the lining of the stomach associated with acute gastritis and acute exacerbation of chronic gastritis.
Excerpted from Wikipedia’s “lafutidine” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0