LCTL
Sign in to saveAlso known as KLG, KLPH, lactase like
Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.
In the Vinony graph
Vinony's link graph records 2 inbound references to LCTL, and connects out to PubMed, human chromosome 15 and alternative mRNA splicing, via spliceosome.
It is catalogued under the topic Genes on human chromosome 15.
Vinony links it to 5 Wikipedia language editions.
Gene data
LCTL- Name
- lactase like
- Type
- protein-coding
- Position
- 66,547,179–66,566,003 (−)
- Aliases
- KLG, KLPH
- Ensembl
- ENSG00000188501
- RefSeq RNA
- NM_001278562.3, NM_001394632.1, NM_001394633.1, NM_207338.4, NR_103739.3
- RefSeq protein
- NP_001265491.1, NP_001381561.1, NP_001381562.1, NP_997221.2
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
lactase like
- Symbol
- LCTL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:66,547,179-66,566,003
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 70710
- exact match
- identifiers.org/ncbigene/197021
- chromosome
- human chromosome 15
- genomic start
- 66839517
- genomic end
- 66565998
- cytogenetic location
- 15q22.31
- found in taxon
- Homo sapiens
- expressed in
- putamen
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.
== Function == This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Excerpted from Wikipedia’s “LCTL” article, available under the CC BY-SA 4.0 licence.