LGALS3

Also known as CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.

Gene data

LGALS3

Name: galectin 3
Type: protein-coding
Position: 55,121,352–55,148,027 (+)
Aliases: CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2
Ensembl: ENSG00000131981
RefSeq RNA: NM_001177388.1, NM_001357678.2, NM_002306.4, NR_003225.2
RefSeq protein: NP_001344607.1, NP_002297.2

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014].

Pathways

Innate Immune System Innate Immune System Immune System Immune System Generic Transcription Pathway Neutrophil degranulation RNA Polymerase II Transcription Gene expression (Transcription)Advanced glycosylation endproduct receptor signaling Transcriptional regulation by RUNX2

via MyGene.info

Gene · Ensembl

galectin 3

Symbol: LGALS3
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:55,121,352-55,148,027
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein LGALS3 PDB 1a3k.png

Show 8 more facts

HomoloGene ID: 37608
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3958
genomic end: 55145423
genomic start: 55590828
chromosome: human chromosome 14
cytogenetic location: 14q22.3
expressed in: amniotic fluid

Sources (5)

via Wikidata · CC0

~10 min read

Encyclopedic overview

13 sections

Contents

Function
Clinical significance
Early neurodevelopment
Brain injury and stroke
Fibrosis
Cardiovascular disease
Cancer
Clinical applications
Cardiovascular risk indicator
Drug development
Biomarkers
Interactions
References

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.

Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.

Excerpted from Wikipedia’s “LGALS3” article, available under the CC BY-SA 4.0 licence.