LIMA1

Also known as EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

Gene data

LIMA1

Name: LIM domain and actin binding 1
Type: protein-coding
Position: 50,175,788–50,283,524 (−)
Aliases: EPLIN, LDLCQ8, SREBP3
Ensembl: ENSG00000050405
RefSeq RNA: NM_001113546.2, NM_001113547.2, NM_001243775.2, NM_001394886.1, NM_001394887.1
RefSeq protein: NP_001107018.1, NP_001107019.1, NP_001230704.1, NP_001381815.1, NP_001381816.1

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

cell migration cell migration

Article

2 sections

Contents

References
Further reading

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM]