LPXN

Also known as LDPL, leupaxin

Leupaxin is a protein that in humans is encoded by the LPXN gene.

Gene data

LPXN

Name: leupaxin
Type: protein-coding
Position: 58,526,871–58,578,220 (−)
Aliases: LDPL
Ensembl: ENSG00000110031
RefSeq RNA: NM_001143995.3, NM_001307951.2, NM_004811.3, XM_011545390.3, XM_011545393.4
RefSeq protein: NP_001137467.1, NP_001294880.1, NP_004802.1, XP_011543692.1, XP_011543695.1

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].

Gene Ontology

Biological process

cell adhesion

~1 min read

Article

2 sections

Contents

References
Further reading

Leupaxin is a protein that in humans is encoded by the LPXN gene.

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.