LMAN1
Sign in to saveAlso known as ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, lectin, mannose binding 1
Protein ERGIC-53 also known as ER-Golgi intermediate compartment 53 kDa protein or lectin mannose-binding 1 is a protein that in humans is encoded by the LMAN1 gene.
In the Vinony graph
Within Vinony's link graph, LMAN1 is referenced by 84 other articles, and connects out to COPII, AP-type membrane coat adaptor complex and PubMed.
It is catalogued under the topic Genes on human chromosome 18.
Its subject is documented across 6 Wikipedia language editions.
Gene data
LMAN1- Name
- lectin, mannose binding 1
- Type
- protein-coding
- Position
- 59,327,823–59,359,417 (−)
- Aliases
- ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58
- Ensembl
- ENSG00000074695
- RefSeq RNA
- NM_005570.4
- RefSeq protein
- NP_005561.1
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lectin, mannose binding 1
- Symbol
- LMAN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:59,327,823-59,359,417
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein LMAN1 PDB 1r1z.png
Show 8 more facts
- HomoloGene ID
- 4070
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3998
- genomic end
- 59359265
- genomic start
- 56995055
- chromosome
- human chromosome 18
- cytogenetic location
- 18q21.32
- expressed in
- seminal vesicula
Sources (7)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Protein ERGIC-53 also known as ER-Golgi intermediate compartment 53 kDa protein or lectin mannose-binding 1 is a protein that in humans is encoded by the LMAN1 gene.
== Function ==
Excerpted from Wikipedia’s “LMAN1” article, available under the CC BY-SA 4.0 licence.