mafenide

Also known as Sulfamylon, 4-Homosufanilamide, Maphenidum, Bensulfamide, 4-(aminomethyl)benzenesulfonamide

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

In the Vinony graph

Vinony's link graph records 154 inbound references to mafenide, and connects out to sulfamethazine, antibiotic and chemotherapy.

Vinony files it under Aminomethyl compounds, Carbonic anhydrase inhibitors and Drugboxes which contain changes to verified fields.

Vinony links it to 11 Wikipedia language editions.

Chemical data

Formula: C7H10N2O2S
Molecular weight: 186.23 g/mol
IUPAC name: 4-(aminomethyl)benzenesulfonamide
SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N
InChIKey: TYMRLRRVMHJFTF-UHFFFAOYSA-N
XLogP: -0.7
Polar surface area: 94.6 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1969
Admin. routes: topical
Indications: osteomyelitis

via ChEMBL · EBI

Research

291 papers

Mafenide acetate cream: a review.Drugs · 1971
Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue.Prehospital and disaster medicine · 2001
Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis.Journal of cellular and molecular medicine · 2021
Mafenide-induced pseudochondritis.The Journal of burn care & rehabilitation · 1988
The mafenide story.The British journal of dermatology · 1973

via PubMed

Wikidata facts

Mass: 186.046299
Has use: medication

Show 4 more facts

chemical formula: C₇H₁₀N₂O₂S
medical condition treated: bacterial infectious disease
canonical SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N
Commons category: Mafenide

Sources (2)

via Wikidata · CC0

~2 min read

Encyclopedic overview

8 sections

Contents

Uses
Mechanism of action
Adverse reactions
Drug interactions
Contraindications
Dosage
References
External links

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

==Uses== Mafenide is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.

Excerpted from Wikipedia’s “mafenide” article, available under the CC BY-SA 4.0 licence.