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GeneQ18037046· pop 6· linked from 4 articles

MCF2L

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Also known as ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to MCF2L, and connects out to PubMed, human chromosome 13 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 13.

Vinony links it to 6 Wikipedia language editions.

Gene data

MCF2L

Name: MCF.2 cell line derived transforming sequence like
Type: protein-coding
Position: 112,894,330–113,100,412 (+)
Aliases: ARHGEF14, DBS, OST
Ensembl: ENSG00000126217
RefSeq RNA: NM_001112732.3, NM_001320815.2, NM_001320816.2, NM_001320817.2, NM_001366644.2
RefSeq protein: NP_001106203.2, NP_001307744.1, NP_001307745.1, NP_001307746.1, NP_001353573.1

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

Gene Ontology

Biological process

positive regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction regulation of small GTPase mediated signal transduction

Molecular function

guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity protein binding phosphatidylinositol binding

Cellular component

extracellular region cytoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol plasma membrane

Pathways

Signal Transduction NRAGE signals death through JNK p75 NTR receptor-mediated signalling Signaling by Rho GTPases Cell death signalling via NRAGE, NRIF and NADE Signaling by GPCR GPCR downstream signalling G alpha (12/13) signalling events Death Receptor Signaling RHOA GTPase cycle

via MyGene.info

Gene · Ensembl

MCF.2 cell line derived transforming sequence like

Symbol: MCF2L
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:112,894,330-113,100,412
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MCF2L PDB 1kz7.png

Show 8 more facts

HomoloGene ID: 11804
genetic association: osteoarthritis
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23263
genomic end: 113099742
genomic start: 113548692
chromosome: human chromosome 13
cytogenetic location: 13q34

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.

== References ==

Excerpted from Wikipedia’s “MCF2L” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 13