RAPGEF5

Also known as GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

In the Vinony graph

Within Vinony's link graph, RAPGEF5 is referenced by 4 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 7.

Its subject is documented across 6 Wikipedia language editions.

Gene data

RAPGEF5

Name: Rap guanine nucleotide exchange factor 5
Type: protein-coding
Position: 22,117,700–22,357,170 (−)
Aliases: GFR, MR-GEF, MRGEF, REPAC
Ensembl: ENSG00000136237
RefSeq RNA: NM_001367600.2, NM_001367601.1, NM_001367602.2, NM_001367603.1, NM_012294.5
RefSeq protein: NP_001354529.1, NP_001354530.1, NP_001354531.1, NP_001354532.1, NP_036426.4

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

small GTPase-mediated signal transduction small GTPase-mediated signal transduction Ras protein signal transduction nervous system development Rap protein signal transduction

Molecular function

guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity protein binding GTP-dependent protein binding

Cellular component

nucleus nucleus nucleoplasm plasma membrane nuclear body

Pathways

Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Pathways in clear cell renal cell carcinoma Ras signaling

via MyGene.info

Gene · Ensembl

Rap guanine nucleotide exchange factor 5

Symbol: RAPGEF5
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:22,117,700-22,357,170
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein RAPGEF5 PDB 1wgy.png

Show 7 more facts

HomoloGene ID: 56563
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9771
genomic end: 22357154
genomic start: 22118236
chromosome: human chromosome 7
cytogenetic location: 7p15.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]

Excerpted from Wikipedia’s “RAPGEF5” article, available under the CC BY-SA 4.0 licence.